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Similarly, elamipretide (ELAM) shows promise in treating HF by restoring the balance between mitochondrial fusion and fission, enhancing fusion through upregulation of MFN1, MFN2, and OPA1 and inhibiting fission by downregulating Fis1 and DRP1 [87]
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Acyl-CoA analysis by LC-MS For extraction of acyl-CoAs, culture medium was completely aspirated from cells in 6cm plates before adding 1ml ice-cold 10% trichloroacetic acid to plates
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