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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Nowak M, Brown TD, Graham A, Helgeson ME, Mitragotri S

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They are fundamentally different classes of peptides working on different receptor pathways Their combination (CagriSema) delivered 22.7% mean weight loss at 68 weeks vs 16.1% for Semaglutide alone and 11.8% for Cagrilintide alone in the REDEFINE 1 trial In type 2 diabetics, CagriSema achieved 13.7% weight loss vs 3.4% with placebo at 68 weeks The side effects of CagriSema are comparable to semaglutide alone, though GI events and injection site reactions are somewhat higher with the combination What Most People Get Wrong About Cagrilintide vs Semaglutide First, let’s clear up the fundamental confusion that’s plaguing this entire conversation