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Following the landmark study, LOTIS-2, LT was evaluated in combination with other targeted therapies, such as ibrutinib in LOTIS-3 and the monoclonal anti-CD20 antibody, rituximab, against R-GemOX (Rituximab, Gemcitabine, and Oxaliplatin) in LOTIS-5, but it remains unclear if these combinations will move to clinical application (Table 2)