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Common causes of elevated SHBG: Aging (SHBG tends to rise with age) Hyperthyroidism Certain medications (anticonvulsants, some statins) Liver disease Significant caloric restriction or low-fat diets Common causes of low SHBG: Obesity and visceral fat accumulation Insulin resistance and type 2 diabetes Metabolic syndrome Hypothyroidism High-dose anabolic steroid use In Woodbury’s active adult population — men who may be managing weight, training hard, or managing metabolic risk factors — SHBG abnormalities are common
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