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93 Furthermore, understanding the relationship between hair graying and other health conditions, such as cardiovascular disease and hearing loss, is crucial for developing comprehensive treatment strategies

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Take, for example, the digestive enzyme nicotinamide N-methyltransferase (NNMT), which converts NAM to methylnicotinamide.32 Methylnicotinamide, for its part, can lead to mitochondrial dysfunction, in turn contributing to the pathogenesis of insulin resistance, coronary artery disease, and Parkinson’s 24 — effectively, the opposite of what you’d want from your NAD+ boosting efforts