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While animal models have partially deciphered these mechanisms, human studies face substantial challenges: interindividual microbiota variability and confounding environmental exposures (e.g., antibiotic history) complicate causal inference

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McMurtrey has since replicated this work in his own lab, taking adult blood cells and reprogramming them back into pluripotent stem cells, then differentiating and directing them to reconstruct new 3D tissue types using a variety of biochemical, biomechanical, and nanopatterning cues [105-111]