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We set functional goals at the outset of treatment and track them throughout, because restoring function is the clinical objective that most accurately reflects what fibromyalgia treatment should achieve

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3 Contribution of MMPs in hypertension-induced vascular remodeling and dysfunction The activation of the 72 kDa MMP-2 in vasculature causes hypertrophic maladaptive remodeling and dysfunction in many experimental models of hypertension, such as two-kidney, one-clip (2K-1C) rats (Castro et al., 2008), deoxycorticosterone acetate (DOCA)-salt rats (Watts et al., 2007), and AngII infusion in rodent by osmotic mini-pumps (Ramos et al., 2025)