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Beyond classical apoptosis, autophagy, and necrosis, emerging forms of programmed cell death such as cuproptosis and ferroptosis have attracted extensive attention in recent years ( 3.1 The essence of cuproptosis—metabolic cell death Cuproptosis, a novel form of regulated cell death discovered and named by Tsvetkov et al., in 2022, is a metabolism-dependent programmed cell death pathway that plays a key role in ovarian cancer progression, chemotherapy resistance, and the tumor immune microenvironment (Tian et al., 2023