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Data availability The coordinates and structure factors for the structures of wild type SnCE1 (PDB: 9QTE), SnCE1 C256A (PDB: 9QTF) and SnCE1-SUMO1-PA (PDB: 9QTG) were deposited in the PDB ( The structures of Chlamydia trachomatis ChlaDUB1 in complexes with ubiquitin (PDB: 6GZS) or Coenzyme A (PDB: 6GZT, Hs SIRT1•NAD + •EX527 (PDB: 4I5I), Hs SIRT2•NAD + •TNFn-5 (PDB: 8QT3), Hs SIRT3•NAD + •EX527 (PDB: 4BV3), Ec CobB•HsH4 peptide (PDB: 1S5P) and SUMO1•Daxx (PDB-ID: 4WJQ) are deposited in the PDB
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