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ACSL4 converts polyunsaturated fatty acids (PUFAs) into polyunsaturated fatty acid coenzymes A (PUFA-CoA) to activate them, and then, LPCAT3 esters these polyunsaturated fatty acid coenzymes A (PUFA-CoA) into phospholipids to produce polyunsaturated fatty acid phospholipid (PUFA-PL) substrates for peroxidation reaction (Zheng and Conrad, 2020)
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