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Krisinger, M
Peptide Synthesis
Size:13+2 Case Discount (1oz)
The solvent was evaporated and the crude product purified by flash chromatography on silica gel (8% methanol/CH 2 Cl 2 ), yielding amide 35 (700 mg, 83%) as a yellow solid: 1 H NMR (400 MHz, CDCl 3 ): δ 8.35 (dd, J=8.2, 1.5 Hz, 1H), 8.22 (d, J=8.1 Hz, 1H), 7.64-7.35 (m, 4H), 7.38-7.26 (m, 5H), 7.06 (d, J=7.8 Hz, 2H), 7.17-7.09 (m, 2H), 5.21-5.13 (m, 2H), 5.12 (s, 2H), 4.69 (q, J=5.1 Hz, 1H), 4.55 (q, J=7.25 Hz, 1H), 4.15 (dd, J=11.4, 5.6 Hz, 1H), 4.11-4.02 (m, 1H), 4.07-3.92 (m, 1H), 3.88-3.77 (m, 1H), 3.73-3.67 (m, 1H), 3.64-3.49 (m, 5H), 3.41 (d, J=10.6 Hz, 2H), 3.37-3.30 (m, 2H), 3.29-3.20 (m, 3H), 2.80 (t, J=6.2 Hz, 2H), 2.52 (t, J=7.8 Hz, 2H), 1.90-1.76 (m, 3H), 1.42 (s, 18H), 1.32 (d, J=5.2 Hz, 3H)
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