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However, the PPP depends on the availability of glucose, and if sufficient glucose is not available then reduced NADPH levels may increase intracellular ROS above a certain threshold level that might elicit cell death

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Figure 3A shows that cells exposed to imatinib rapidly accumulated in the G1 phase of the cell cycle within 24 hours and subsequently underwent cell death (represented by the subG1 population), while the treatment with curcumin gradually increased the population in the G2/M phase and induced cell death, indicating that the molecular inhibitory actions of these two components differ