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Constipation in B12 deficiency is primarily neurogenic, due to autonomic and enteric neuropathy causing slow gut motility • Constipation may precede anemia • Often improves after B12 replacement • Think of B12
That distinction matters enormously for understanding both its benefits and its limitations
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This interest is particularly relevant in the broader context of treating male hypogonadism, where testosterone replacement therapy (TRT) remains the standard intervention [3]
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