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CI values for the four primary AML patient samples ranged from 0.021 to 1 ( Supplementary Figures S3A-D ), among those doses two were reproduced in all four samples ( Figure 5B ), indicating a synergistic inhibition of AML cell growth with the combination of BI4916 and Rylaze
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However, other processes such as the donation of glutamine's amido nitrogen to nucleotides or hexosamines could contribute a fraction of the glutamate pool as well
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